Neurodegenerative diseases, a new study from the University of Verona
A new study from the University of Verona on Chorea-acanthocytosis – a hereditary, severely disabling neurodegenerative disease, which usually occurs around 35 years – has been published in the prestigious journal “Blood”.
Supported by the Telethon Foundation, the research is the result of intense collaboration between different teams at the University of Verona, including the Department of Neuroscience, the Anatomy and Biochemistry sections and the University Laboratory for Medical Research (LURM), in the context of an international research network that also involved the University of Dresden, Germany, and the Mount Sinai Medical School of New York.
‘The study – explained the Italian researchers – showed for the first time a link between certain cell abnormalities and autophagy, that is, the cellular mechanism of selective removal of damaged cytoplasmic components: chorein is the protein produced by a specific “altered” gene which, in this disease, leads to the development of neurodegeneration of the basal ganglia of the brain’.
‘The research – the researchers added – paves the way for new studies, with possible therapeutic developments: future prospects involve the use of mutated mice for this disease, developed as part of the Telethon project to assess the effectiveness of a polytherapeutic scheme; pre-clinical studies will allow, in a subsequent phase, clinical trials to be performed for this disease’.